The former Director-General of the South African National Department of Health. She was the World Health Organization Director of Public Health Innovation and Intellectual Property. Shewas the Registrar of the Medicines Control Council for six years. She served on various advisory bodies both nationally and internationally, including Chair of the WHO Executive Board, member of the UN High-Level Panel on Access to Health Technologies, Chairperson of the Independent Oversight and Advisory Committee for the WHO Health Emergencies Programme, member of the Independent Panel for Pandemic Preparedness and Response. She is the Director of the Health Regulatory Science Platform, a division of the Wits Health Consortium and was an Honorary Lecturer in the Department of Pharmacy and Pharmacology, University of the Witwatersrand. She is the member of the Interim Executive Committee of the College for African Regulatory Science Professionals (CARSP), Cochaired the Intergovernmental Negotiating Body for a Pandemic Agreement and Cochaired the G20 Health Working Group. She was appointed Adjunct Professor at Sunway University, Malaysia. She is the recipient of the South African MRC Presidential Lifetime Achievement Award, the UNITAR 2025 best Negotiator Award, Featured in Nature’s 10 and Time 100 Heath for 2026 and Times 100 {Titans). She is the recipient of “Le Forum Galien Afrique award, BHF Titanium Lifetime Achievement Award, KZKDHC Lifetime Achievement Award, She was recognized for her Leadership of the Pandemic Treaty by WHO Director General.